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Regarding Ankylosing Spondylitis (AS)
Basic bone growth and AS
More AS implications
AS pathological physiology
View animations of AS development



Typical ossification occurs as cartilage cells that are determined to become bone, called chondracytes, develop into cells called osteoblasts, that in turn develop into bone tissue. This bone tissue is one of two types, cancellous bone, the inner largely porous bone where blood cells are stored, and cortical bone, which is the strong denser outer bone.

The AS condition provides for abnormal ossification in which the cartilage-to-bone process is bypassed and the osteoblasts that are intended for repair form new bone structures. The osteblasts are deposited in the body's attempt to repair the damage to the bone caused by the enthesopathy.

As the enthesopathy's inflammation cells are infused with blood vessels, osteoblasts assemble at the site of the enthesopathy,

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weaving into the existing bone's cellular matrix, producing small points of new cortical bone called syndamorphytes. These syndamorphytes comprise the bony protusions that ultimately replace the anulus fibrosus' fibrous tissue, thereby fusing the vertebrae as they grow across the intervertebral space.



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